Blood Brothers is a tale about two young men from Botswana, Sasha and Dumisani McDaniels. Sasha is white and Dumisani is black. 'Dumi' was adopted at childbirth, the same day Sasha was born. Even though they are not biological brothers, they are as close as real brothers can be and more. Their parents were nature enthusiasts and documentary filmmakers, who tragically were brutally murdered by blood thirsty poachers, led by the notorious Molo Sahili. After their parents' death, the brothers, now also profound martial artists, decide to move to the United States, their parents' country of origin, where they start a new life. This dream is shattered almost immediately, when they inadvertently and unknowingly witness an armored car heist making them 'loose ends' that the robbers need to tie up. It turns out that the mastermind behind the robbery has strong ties to a man who has his sights set on the White House, so the brothers need to be silenced at all costs. The brothers believe they will be safe in their home country, so they try to make it to the Mexican border on foot and catch a flight back to Botswana. Meanwhile, the pursuers get closer to catching them with every minute that ticks by, and it's a life-or-death race against time.